Effects of cholinergic and adrenergic agents and their antagonists at the neuromuscular junction of the cat extraocular muscles.

D,uke-Elder and Duke-Elder first re ported on the action of choline and nicotine on the mammalian extraocular muscle; this was followed by a study by Brown and Harvey on the cat extrinsic eye muscle. Since then very little investigation has been reported on mammalian extraocular muscle, except by Breinin. Recently, more detailed investigation of cat extraocular muscle has been reported following administration of cholinomimetics, neuromuscular blocking agents, and certain sympathomimetics.'" It is the purpose of this publication to present a summarized account of these and earlier investigations.